Interakcije lekova: pregled literature

AUTOR: Byrne EB

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Byrne EB. Drug interacions: a review and update. Endodontic Topics 2003;4:9-21.

People world wide rely on medications to prevent, cure, or lessen an ever expanding list of diseases. Drugs can be beneficial as well as detrimental. The goal of therapy is to maximize beneficial effects, while trying to minimize the detrimental effects. Each drug prescribed has a risk–benefit ratio. If the benefit of taking the drug out weighs the risk of adverse effects, then the drug therapy is appropriate. Taking one or more drugs that interact may change this risk–benefit ratio. What was once a safe and appropriate drug therapy may now be inappropriate due to an increased risk from a drug interaction. Studies have shown that when the number of co-administered drugs exceeds four, the risk associated with such use for the patient increases substantially